FRIO INSULIN COOLING CASES provide a highly effective, yet low-cost solution to the problem of keeping insulin at a safe temperature without the need for ice packs or refrigeration. The FRIO Cooling Case is a reusable evaporative cooler whose cooling properties do not come from an icepack - or anything that needs refrigeration. HOW LONG DO FRIOS STAY COLD? FRIO wallets keep insulin safe for a minimum of 45 hours (more than five times longer than an ice pack) - even in constant environmental temperatures of 100 degrees Fahrenheit! The insulating qualities of the FRIO also help protect against the cold of winter. HOW DO YOU USE A FRIO? To activate the FRIO wallet, immerse it in cold water for 5-15 minutes. Just towel dry the outside and it's ready to go! After towel-drying, the FRIO wallet is dry to the touch. The Cambrelle outer pouch wallet increases the wallet's efficiency and allows it to be carried safely in your pocket or a bag as required To use it again, put the FRIO back in water - it can be reactivated over and over again.